Matthew 16:26

Lose his own soul - Or, lose his life, την ψυχην αυτου. On what authority many have translated the word ψυχη, in the 25th verse, life, and in this verse, soul, I know not, but am certain it means life in both places. If a man should gain the whole world, its riches, honors, and pleasures, and lose his life, what would all these profit him, seeing they can only be enjoyed during life? But if the words be applied to the soul, they show the difficulty - the necessity - and importance of salvation. The world, the devil, and a man's own heart are opposed to his salvation; therefore it is difficult. The soul was made for God, and can never be united to him, nor be happy, till saved from sin: therefore it is necessary. He who is saved from his sin, and united to God, possesses the utmost felicity that the human soul can enjoy, either in this or the coming world: therefore, this salvation is important. See also the note on Luke 9:25 (note).

For what is a man profited ... - To gain the whole world means to possess it as our own - all its riches, its honors, and its pleasures.

"To lose his own soul" means to be cast away, to be shut out from heaven, to be sent to hell. Two things are implied by Christ in these questions:

1. That they who are striving to gain the world, and are unwilling to give it up for the sake of religion, will lose their souls; and,

2. That if the soul is lost, nothing can be given in exchange for it, or that it can never afterward be saved. There is no redemption in hell.