Genesis 4:16

The land of Nod - As נוד nod signifies the same as נד sa , a vagabond, some think this verse should be rendered, And Cain went out from the presence of the Lord, from the east of Eden, and dwelt a vagabond on the earth; thus the curse pronounced on him, Genesis 4:12, was accomplished.

The presence of the Lord - seems to have been at the entrance of the garden where the cherubim were stationed. There, probably, the children of men still lingered in faith and hope before the Lord, whom they still regarded as their Maker and merciful Saviour. They acknowledged his undeserved goodness in the form of sacrifice. The retreat of Cain from the scene of parental affection, of home associations, and of divine manifestation, must have been accompanied with many a deep, unuttered pang of regret and remorse. But he has deeply and repeatedly transgressed, and he must bear the consequence. Such is sin. Many a similar deed of cruelty and bloodshed might the sacred writer have recorded in the later history of man. But it is the manner of Scripture to note the first example, and then to pass over in silence its subsequent repetitions, unless when a particular transaction has an important bearing on the ways of God with man.

4:16 And Cain went out from the presence of the Lord, and dwelt on the east of Eden - Somewhere distant from the place were Adam and his religious family resided: distinguishing himself and his accursed generation from the holy seed; in the land of Nod - That is, of shaking or trembling, because of the continual restlessness of his spirit. Those that depart from God cannot find rest any where else. When Cain went out from the presence of the Lord, he never rested after.